II. Epidemiology
- Often the first vaso-Occlusion crisis finding in young children (as early as 6 months of age)
- Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
- Rare over age 4 years old
III. Pathophysiology
- Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease
- Occurs in Sickle Cell Anemia with vaso-Occlusion
- Caused by infarction of Bone Marrow
- Metacarpal or Metatarsal Bones and phalanges
IV. Symptoms
- Painful swelling and tenderness of either the hand or foot
- Digits may appear mildly erythematous
V. Signs
- Low grade fever (variably present)
VI. Differential Diagnosis
VII. Course
- Resolves spontaneously within 1 week
VIII. References
- Welsh and Welsh (2016) Crit Dec Emerg Med 30(11): 15-23